Figure 4.

Sex modifies the APOE ε4 dose effect on voxel-wise analysis of ¹⁸F-flortaucipir PET in cognitively impaired participants. APOE ε4 dose effect on voxel-wise SUVR is depicted in (A) females and (B) males. Female heterozygotes (A, left) and homozygotes (A, right) display increased ¹⁸F-flortaucipir SUVR compared to non-carriers. No significant differences in SUVR were observed between female heterozygotes and homozygotes. Male homozygotes demonstrate increased ¹⁸F-flortaucipir SUVR compared to male heterozygotes (B, left) and male non-carriers (B, right). No significant differences in SUVR were observed between male heterozygotes and male non-carriers. T-values are expressed on blue–red scale from 0 to 5 depicting voxels level with P < 0.001 (adjusted for age and years of education).