Table 2.

APOE ε4 dosage × sex interaction effect on tau deposition in cognitively impaired participants

Region of interest	Not adjusted for global cortical amyloid level			Adjusted for global cortical amyloid level
	Standardized β (95% CI)	APOE ε4 × Sex	FDR	Standardized β (95% CI)	APOE ε4 × Sex	FDR
		P-value	P-value		P-value	P-value
Orbital frontal	−0.08 (−0.13 to 0.05)	0.04	0.06	−0.02 (−0.11 to 0.10)	0.82	0.95
Prefrontal	−0.07 (−0.13 to 0.06)	0.12	0.14	−0.01 (−0.11 to 0.09)	0.88	0.95
Superior frontal	−0.03 (−0.13 to 0.09)	0.38	0.38	−0.01 (−0.13 to 0.12)	0.80	0.95
Lateral temporal	−0.03 (−0.12 to 0.18)	0.02	0.04	0.09 (−0.09 to 0.25)	0.20	0.43
Parietal	0.00 (−0.14 to 0.14)	0.18	0.20	0.03 (−0.13 to 0.18)	0.57	0.93
Posterior precuneus	−0.06 (−0.20 to 0.09)	0.05	0.07	−0.03 (−0.18 to 0.14)	0.96	0.96
Posterior cingulate	0.01 (−0.16 to 0.18)	0.02	0.04	0.06 (−0.13 to 0.25)	0.30	0.56
Medial temporal	0.15 (−0.01 to 0.21)	0.002	0.01	0.22 (0.04 to 0.28)	0.006	0.03
Inferior temporal	0.03 (−0.14 to 0.19)	0.03	0.05	0.10 (−0.08 to 0.29)	0.16	0.42
Entorhinal cortex	0.21 (0.03 to 0.33)	<0.001	<0.001	0.30 (0.12 to 0.47)	<0.001	0.001
Amygdala	0.12 (−0.04 to 0.26)	0.008	0.03	0.19 (0.02 to 0.37)	0.02	0.07
Parahippocampal	0.16 (−0.01 to 0.21)	<0.001	<0.001	0.23 (0.04 to 0.29)	0.002	0.01

P-value was defined using a generalized linear model to detect significant APOE ε4 dosage × sex interaction effect in cognitively impaired individuals. Age and education were included as covariates. Global cortical amyloid SUVR was also included as a covariate in the right column using 188 individuals with ¹⁸F-florbetapir PET data. FDR P-value was defined using Benjamini–Hochberg procedure to control the FDR; 95% CI represents the 95% confidence interval of the APOE ε4 dosage by sex coefficient.