Table 3.

Clusters with significant association between ¹⁸F-flortaucipir SUVR and APOE ε4 dosage

Clusters	Female						Male
	Homozygotes > non-carriers			Heterozygotes > non-carriers			Homozygotes > non-carriers			Homozygotes >heterozygotes
	x	y	z	x	y	z	x	y	z	x	y	z
Temporal_Mid_L Temporal_Inf_L	−63	−28.5	−21	55	−66	0	−54	−26	−5	−	−	−
Temporal_Mid_R Temporal_Inf_R	−	−	−	55	−21	−21	58	−21	−7	60	−30	0
Temporal_Sup_R	−	−	−	64.5	−33	16.5	57	−6	2	−	−	−
ParaHippocampal_L Amygdala_L	−18	−9	−18	−22	−12	−25	−18	−6	−21	−	−	−
ParaHippocampal_R Amygdala_R	18	−7.5	−18	18	−7.5	−18	18	−4	−22	−	−	−
Cingulum_Mid_L Precuneus_L	−	−	−	-6	−43	20	9	−27	36	−6	−22	36
										−	−	−
Cingulum_Mid_R Precuneus_R	−	−	−	9	−43	26	9	−24	41	10.5	−51	45
Parietal_Inf_L	−52.5	−52.5	42	−44	−48	40	−42	−48	43	9	−57	58.5
Parietal_Inf_R	34.5	−52.5	46.5	−	−	−	45	−53	53	33	−54	54
Parietal_Sup_L	−31.5	−63	60	−30	−67.5	57	−24	−67	51	−	−	−
Frontal_Mid_L Frontal_Sup_L	−	−	−	−	−	−	−4	59	17	−	−	−
Frontal_Mid_R Frontal_Sup_R	28.5	34.5	36	−	−	−	13.5	27	57	−	−	−

Data extracted from SPM12 analysis showing voxels with significantly increased ¹⁸F-flortaucipir SUVR in cognitively impaired female APOE ε4 homozygotes versus non-carriers, female heterozygotes versus female non-carriers, male APOE ε4 homozygotes versus male non-carriers, male homozygotes versus male heterozygotes, adjusted for age and years of education. There were no significant differences between female homozygotes and female heterozygotes or between male heterozygotes and male non-carriers (not listed in Table 3). Cluster locations correspond to the brain maps shown in Fig. 3. Atlas coordinates were obtained from Automated Anatomical Labelling (AAL).⁴⁰