Figure EV3. TAZKO causes cardiomyopathy in mice.

TAZKO mice (5 months old) were compared to littermate controls (WT).

1. Heart tissue was analyzed by quantitative electron microscopy. Lipid droplets are marked by asterisks. Graphs show mean values and standard deviations. Multiple micrographs were analyzed in three biological replicas.
2. Anesthetized mice were subjected to a pharmacologic stress test by isoproterenol infusion. Cardiac performance was analyzed by echocardiography.

Data information: The graphs show mean values and standard deviations of the indicated number of biological replicas. Means were compared by Student’s t‐test.