Figure EV1. CDKL5 kinase.

1. The CMGC branch of the human kinome. The figure is taken from the dendrogram made by Manning and colleagues (Manning et al, 2002). The CDKL family of kinases that includes CDKL5 is encircled in red.
2. (Top) Schematic diagram of CDKL5 protein. (Bottom) Bioinformatics analysis for CDKL5 folding using Fold index software (Prilusky et al, 2005). The plot shows the disorder prediction for CDKL5 protein sequence. Ordered regions are indicated in green above 0, while disordered regions are indicated in red below 0. Amino acids suggested as being folded or unfolded are depicted at the bottom of the plot. The region that mediates recruitment of CDKL5 to DNA damage sites is marked in pink.