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Potential effects of leptin in adaptive immune cells.
| Cell Type | Ob-R Expression | Cytokine | Effect | Stage |
|---|---|---|---|---|
| CD4+ | Yes | IL-2, IFN-γ | -Activation* -Proliferation -Survival -Promotion a bias toward T helper 1-cell |
Pro-inflammatory |
| CD8+ | Yes | IL-2, IFN-γ | -Activation* -Proliferation -Survival |
Pro-inflammatory |
| Tregs | Yes | IL-2 | -Inhibition of proliferation | Pro-inflammatory |
*Previous lectin phytohemagglutinin (PHA) or concanavalin A stimulation is required (90) Tregs, T regulatory cells.
