Figure 1.

Hypothesized interactions between platelets and adenoviruses. Adenoviruses (Ad) induce platelet activation either by binding to platelet coxsackie and adeno - virus receptor (CAR) or to plateletsurface integrins, such as αvb3 or α5b1. Moreover, circulating Ad-elicited IgG or immune complexes may directly activate platelets through FcgRIIa. Gas6 exposed by cerebral vein endothelial cells may bind Ad and activate platelets acting on Tyro3, Axl and Mer (TAM) receptors. Ad may also bind CAR expressed by cerebral vein vessels in this way activating endothelial cells which in turn may elicit platelet activation.