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. 2020 Oct 13;106(12):3149–3161. doi: 10.3324/haematol.2019.241745

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Copyright© 2021 Ferrata Storti Foundation

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Figure 1. — Cell-type specific effect of Hfe deletion on the course of systemic Salmonella infection. Survival (A, E and I) and bacterial load in spleen (B, F and J), liver (C, G and K) and serum (D, H and L) of Hfe^-/- (A-D) mice and mice lacking Hfe in hepatocytes (AlfpCre⁺ Hfe^fl/fl in E-H) or macrophages (LysMCre⁺ Hfe^fl/fl in I-L), respectively, compared to matched controls. Mice were infected with 500 colony forming units (CFU) of S. enterica serovar Typhimurim by intraperitoneal injection and monitored for 14 days (336 hours ). Data represent two independent experiments. Statistics: survival data between control and mutant mice were compared using the Log-rank (Mantel-Cox) Test. n=18 for Hfe^+/+, n=16 for Hfe^-/-, n=13 for AlfpCre^- Hfe^fl/fl, n=9 for AlfpCre⁺ Hfe^fl/fl, n=16 for LysMCre^- Hfe^fl/fl, n=15 for LysMCre⁺ Hfe^fl/fl. Log CFU data of tissue bacterial load of randomly selected mice euthanized after 72 hours of Salmonella infection were compared using student t-test. CFU data of serum bacterial load were compared by Mann-Whitney test. n=12 for Hfe^+/+, n=12 for Hfe^-/-, n=20 for AlfpCre^- Hfe^fl/fl, n=14 for AlfpCre+ Hfefl/fl, n=10 for LysMCre^- Hfe^fl/fl, n=10 for LysMCre⁺ Hfe^fl/fl.