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. 2020 Oct 13;106(12):3149–3161. doi: 10.3324/haematol.2019.241745

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Figure 6. — Elevated iron levels correlate with reduced IFN-g production and increased bacterial numbers in the serum. Serum complement factor C3 (A), IL-6 (B) and IFN-γ (C) concentrations were analyzed in AlfpCre⁺ Hfe^fl/fl mice infected for 72 hours with Salmonella. n=19-20 for AlfpCre^– Hfe^fl/fl, n=8-14 for AlfpCre⁺ Hfe^fl/fl. sIndependently, wild-type (WT) mice were fed an iron-adequate (IA) or iron-enriched diet (IO) 3 weeks prior to and during S. enterica Typhimurium (S. Tm.) infection. Serum bacterial load (D), IL-6 (E) and IFN-g (F) concentrations were determined. Statistically significant differences as calculated by Mann-Whitney test are indicated. n= 8-9 for IA, n=8 for IO.