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. 2021 Nov 15;9:713925. doi: 10.3389/fcell.2021.713925

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Copyright © 2021 Wu, Li, Yang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Landscape of 33 pyroptosis-related genes (PRGs) in hepatocellular carcinoma. (A) The occurrence of copy number variation (CNV) and somatic mutations of 33 PRGs in The Cancer Genome Atlas—Hepatocellular Carcinoma (TCGA-HCC): among 364 samples, 53 experienced mutations with a frequency of 14.56%, and NLRP2/3 demonstrated the highest mutation frequency. (B) The analysis of CNV alteration frequency displayed that CNV changes were common in 33 PRGs; the result indicated that GSDMC, AIM2, and GSDMD had a general frequency of CNV gain, and CASP9 had a widespread frequency of CNV loss. (C) The expression of 33 PRGs between normal and tumor cells in TCGA-HCC. (D) The impact of 33 PRGs on EA or ES in different cancer types; the result suggested that CASP family genes mainly affect EA, whereas the NLRP family genes mainly affect ES; pink represents EA and green represents ES. EA, epigenetically activated; ES, epigenetically silenced. The asterisks represent the statistical p-value (*p < 0.05; **p < 0.01; ***p < 0.001).