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. 2021 Nov 15;9:713925. doi: 10.3389/fcell.2021.713925

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Copyright © 2021 Wu, Li, Yang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cluster and biological function based on the expression of 336 differentially expressed lncRNAs. (A) Three different clusters were identified by the unsupervised clustering method, and the cluster 2 model indicated an especially survival disadvantage. (B) The heatmap of the top 20 long non-coding RNAs (lncRNAs) associated with favorable and poor overall survival (OS) and clinicopathological manifestations; the result shows that the expression of lncRNA in cluster 2 is obviously heterogeneous. (C) Cluster 1 was prominently correlated to cancer development, such as glioma and small-cell lung cancer. (D) Cluster 3 was mainly enriched in pathways related to metabolism activation such as fatty acid metabolism, beta alanine metabolism. N, lymph node; N0, the lymph nodes are not affected; N1, the lymph nodes are affected; NX, unevaluated; M, metastasis; M0, no metastasis; M1, metastasis; MX, unevaluated; T, primary tumor.