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. 2021 Nov 15;9:713925. doi: 10.3389/fcell.2021.713925

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Copyright © 2021 Wu, Li, Yang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The result of alteration frequency and tumor mutation burden (TMB) between the high- and low-risk group. (A) The top 20 driver genes with the highest alteration in the high-risk group. (B) The top 20 driver genes with the highest alteration in the low-risk group. (C) The connection among the high-/low-score group and TMB, and the results show that the high TMB group demonstrated a poorer prognosis. (D) When high/low TMB is randomly combined with high/low risk, and high TMB is combined with a high risk score indicated a poorer prognosis.