Results of the histologic analysis of pancreas
from mice treated
with vehicle (control), cerulein, and cerulein plus either 0.1 or
0.3 mg/kg of compound 22. (A) Representative H&E-stained
sections of the pancreas from the in vivo efficacy
study. Arrows indicate inflammatory cells and edema. Bold arrows indicate
intracellular vacuoles. (B–E) Histologic scoring of pancreatic
tissues. (B), edema. (C), inflammatory cells (mononuclear and polymorphonuclear).
(D), parenchymal atrophy. (E), total scoring (pancreatic parenchymal
atrophy, vacuolar degeneration of cells, edema, hemorrhage, mononuclear
inflammatory cells, mononuclear inflammatory cells, polimorfonuclear
inflammatory cells and necrosis). *p < 0.05, **p < 0.01 and ***p < 0.001 vs control. #p < 0.05 vs cerulein.