Skip to main content
. 2021 Aug 18;113(12):1683–1692. doi: 10.1093/jnci/djab124

Figure 3.

Figure 3.

Somatic mutation analyses. Comparison of somatic tumor mutation analyses between EO-CRC and AO-CRC. A) Frequency of oncogenic alterations by age group (35 years and younger, 36-49, 50 years and older [AO-CRC]). B) Frequency of oncogenic alterations adjusted for primary tumor location (left vs right vs rectum) between the 35 years and younger and AO cohorts. C) Frequency of oncogenic alterations adjusted for primary tumor location (left vs right vs rectum) between the 36-49 and AO cohorts. D) Response to first-line chemotherapy. E) Survival outcomes by age groups. F) Multivariate survival analysis incorporating clinical and genomic characteristics that were statistically significant on univariate analysis, as well as age. All statistical tests were 2-sided. AIC = Akaike information criterion; AO = average onset; CI = confidence interval; CRC = colorectal cancer; EO = early-onset; FSM = first sites of metastasis; HAI = hepatic arterial infusion; Dif = differentiated; Mod = moderately; Pw = Pathway.