TABLE 1.
General characteristics of in vivo and in vitro studies included in the scoping review1
| Country | Type of study | Experimental model: in vivo | Experimental model: in vitro | Type of Caps intervention | Caps intervention time: in vivo | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reference | USA | China | Japan | India | In vivo | In vitro | C57BL/6–WT mice | C57BL/6 -TRPV1−/− mice | db/db Mice | ob/ob Mice | Wistar rats | LACA | HEK293 | 3T3-L1 | Mouse brown adipocyte (primary culture) | Mouse white adipocyte (primary culture) | Human white adipocyte (primary culture) | Oral–via diet | Oral–via gavage | Incubation (cell-cell culture) | Up to 12 wk | 16–20 wk | 32–38 wk |
| Baboota et al. (78) | – | – | – | X | X | X | – | – | – | – | X | X | X | – | – | – | – | X | X | X2 | – | – | |
| Baskaran et al. (73) | X | – | – | – | X | X | X | X | – | – | – | – | X | – | – | X | – | X | – | X | – | – | X |
| Baskaran et al. (79) | X | – | – | – | X | X | X | X | – | – | – | – | X | – | X | – | – | X | – | X | – | X | X |
| Chen et al. (72) | – | X | – | – | X | X | X | X | X | – | – | – | – | X | – | – | X | X | – | X | – | X | – |
| Fan et al. (77) | – | X | – | – | – | X | – | – | – | – | – | – | – | X | – | – | – | – | – | X | – | – | – |
| Kida et al. (75) | – | – | X | – | X | X | X | – | – | – | – | – | – | – | X | – | – | – | – | X | – | – | – |
| Kida et al. (76) | – | – | X | – | – | X | – | – | – | – | – | – | – | – | X | – | – | – | – | X | – | – | – |
| Krishnan et al. (74) | X | – | – | – | X | X | – | – | X | – | – | – | X | X | – | X | – | X | – | X | – | – | X |
| Zhang et al. (71) | – | X | – | – | X | X | X | X | X | X | – | – | – | X | – | – | – | X | – | X | X | X | – |
1The included studies were published between the years 2007 and 2019 (n = 9). The “X” symbol represents the presence of the characteristic in the study. The “-” symbol represents the absence. Caps, capsaicin; TRPV1, transient receptor potential vanilloid 1; WT, wild-type.
2Administration on alternate days.