Table 2.
Univariate and multivariate COX regression analysis of clinical factors and OLFML2B on overall survival of patients with bladder cancer.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| TCGA-BLCA | ||||
| Age | 1.04(1.02-1.06) | 3.69E-05 | 1.04(1.02-1.06) | 1.66E-04 |
| Gender | 0.85(0.59-1.22) | 3.74E-01 | 0.84(0.59-1.21) | 3.60E-01 |
| Grade | 26257554.67(0-Inf) | 9.95E-01 | 3539739.69(0-Inf) | 9.92E-01 |
| T stage | 1.76(1.38-2.25) | 6.40E-06 | 1.77(1.37-2.29) | 1.61E-05 |
| OLFML2B | 1.15(1.04-1.27) | 6.37E-03 | 1.08(0.98-1.2) | 1.22E-01 |
| GSE13507 | ||||
| Age | 1.07(1.04-1.1) | 4.53E-08 | 1.07(1.04-1.1) | 3.07E-07 |
| Gender | 0.64(0.36-1.14) | 1.29E-01 | 0.78(0.42-1.43) | 4.19E-01 |
| Grade | 2.74(1.69-4.43) | 4.00E-05 | 0.94(0.51-1.71) | 8.33E-01 |
| T stage | 2.05(1.64-2.58) | 5.06E-10 | 2.09(1.57-2.79) | 4.78E-07 |
| OLFML2B | 1.65(1.24-2.2) | 5.46E-04 | 1.03(0.72-1.48) | 8.67E-01 |
| E-MTAB-1803 | ||||
| Age | 0.99(0.96-1.02) | 6.83E-01 | 1(0.97-1.03) | 8.35E-01 |
| Gender | 1.08(0.45-2.59) | 8.63E-01 | 1.8(0.7-4.64) | 2.23E-01 |
| Grade | 0.88(0.31-2.49) | 8.12E-01 | 1.08(0.38-3.11) | 8.84E-01 |
| T stage | 2.92(1.88-4.53) | 1.74E-06 | 3.04(1.92-4.83) | 2.34E-06 |
| OLFML2B | 1.31(0.97-1.75) | 7.39E-02 | 1.4(1.02-1.92) | 3.90E-02 |
| GSE32548 | ||||
| Age | 1.04(0.99-1.08) | 9.34E-02 | 1.05(1.01-1.1) | 2.82E-02 |
| Gender | 1.29(0.48-3.43) | 6.13E-01 | 1.37(0.49-3.84) | 5.50E-01 |
| Grade | 2.26(1.07-4.77) | 3.26E-02 | 0.62(0.21-1.83) | 3.85E-01 |
| T stage | 3.53(1.89-6.6) | 7.42E-05 | 4.22(1.69-10.5) | 1.98E-03 |
| OLFML2B | 2.19(1.48-3.24) | 9.12E-05 | 1.47(0.9-2.41) | 1.26E-01 |
| GSE32894 | ||||
| Age | 0.98(0.95-1.01) | 1.79E-01 | 0.96(0.91-1.01) | 8.44E-02 |
| Gender | 1.47(0.55-3.93) | 4.45E-01 | 1.13(0.42-3.06) | 8.14E-01 |
| Grade | 7.59(2.45-23.52) | 4.45E-04 | 5.8(1.82-18.45) | 2.91E-03 |
| T stage | 0.98(0.62-1.56) | 9.42E-01 | 0.96(0.58-1.6) | 8.87E-01 |
| OLFML2B | 2.06(1.49-2.86) | 1.56E-05 | 1.62(1.11-2.35) | 1.27E-02 |
HR, hazard ratio; CI, confidence interval; Inf, infinity.
Bold means p < 0.05.