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. 2021 Nov 15;8:739212. doi: 10.3389/fcvm.2021.739212

Figure 5.

Figure 5

(A) Immunofluorescence stains of PAR2, iNOS, ad DAPI and their merged images of macrophages are demonstrated. Columns indicated the mean fluorescence intensity of PAR2 and iNOS of macrophages exposed to FXa at 2.0 U/L and treated with rivaroxaban at concentrations of 0, 50, 100, and 200 mmol/L. (B) Immunoblots of PAR2, iNOS, and GAPDH. Columns indicate the relative expression levels of PAR2 and iNOS in macrophages exposed to FXa at 2.0 U/L and treated with rivaroxaban at concentrations of 0, 50, 100, and 200 mmol/L. (C) Columns indicate the concentrations of IL1, IL6, and TNFα in the cell culture medium of macrophages exposed to FXa at 2.0 U/L and treated with rivaroxaban at concentrations of 0, 50, 100, and 200 mmol/L (data were presented as mean ± SD, n = 6, Student's t-test and ANOVA, *P < 0.05).