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. 2021 Nov 15;8:739212. doi: 10.3389/fcvm.2021.739212

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Copyright © 2021 Ma, Zhang, Qiu, He, He, Shi and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Immunofluorescence stains of MYH11, DAPI, and their merged images are demonstrated. Columns indicate the mean fluorescence intensity of MYH11 in VSMCs co-cultured with rivaroxaban-treated or un-treated macrophages exposed to FXa in the contact co-culturing model. (B) Columns indicate the measured collagen content of VSMCs co-cultured with rivaroxaban-treated or un-treated macrophages exposed to FXa in the contact co-culturing model. (C) Immunoblots of NICD1, HES1, and GAPDH are demonstrated. Columns indicate the relative expression levels of NICD1 and HES1 in VSMCs co-cultured with rivaroxaban-treated or un-treated macrophages exposed to FXa in the contact co-culturing model (data were presented as mean ± SD, n = 6, Student's t-test and ANOVA, *P < 0.05).