TABLE 4.

Indirect regulators targeting the cGAS-STING pathway.

Agents	Inhibition mechanism	Biological effect	Refs
Obtusilactone B, Brazilin	It inhibits dsDNA by inhibiting BAF	Indirect regulation of cGAS	Kim et al. (2013b); Kim et al. (2015)
Tucatinib	Inhibition of HER2 kinase activity	Indirect regulation of STING	Kulukian et al. (2020)
EGCG	Inhibits the enzyme activity of G3BP1	Indirect regulation of cGAS	Liu et al. (2019)
Compound C	Inhibit the accumulation of cGAMP	Indirect regulation of the cGAS-STING pathway	Lai et al. (2020)
Celastrol	Inhibit the activation of IRF3	Indirect regulation of the cGAS-STING pathway	Liu et al. (2020)
α,β−metADP/ATP,bzATP, ARL 67156	Inhibit the activation of ENPP1	Indirect regulation of the cGAMP	Lévesque et al. (2007); Lee et al. (2017)
(TiW11CoO40)8−, SR-8314, MV-626	Inhibit the activation of ENPP1	Indirect regulation of the cGAMP	Lee and Müller, (2017); Weston et al. (2019)