Across 14 days of fixed ratio 1 (FR1) in the males using Bussey touchscreen chambers, maternal HF diet (A) increased trials performed on days 2 and 4–13, (B) reduced blank or incorrect touches on days 10–13, and (C) increased accuracy on days 2 and 4–13. Across the 15 days of FR1 in the females using ROBuckets, there were no significant differences in (D) active pokes, (E) inactive pokes, or (F) accuracy. (n = 15–16/group) (HF = offspring of maternal high fat diet; CD = offspring of maternal control diet; PLX = adolescent PLX3397 treatment; NT = not treated during adolescence) (Graph title = # interaction between perinatal diet and day, HF * main effect of diet; *p < 0.05 HF vs. CD)