Male 5 choice serial reaction time task (5CSRTT) (A) With the 16 s stimulus, HF diet decreased the percent of omissions. (B) With the 8 s stimulus, PLX treatment decreased the percent of incorrect errors. (C) Then with the most challenging 4 s stimulus, PLX reduced premature responses specifically in the HF PLX vs. HF NT group. (D) Premature responses with the 4 s stimulus were significantly correlated with peak FR1 responses (day 12), specifically in the HF NT group. (E) With a titrated stimulus, HF diet and PLX treatment had an interaction effect on the percent of omissions but not post hocs reached significance. (F) There were no differences in the minimum achieved stimulus. (n = 15–16/group) (HF = offspring of maternal high fat diet; CD = offspring of maternal control diet; PLX = adolescent PLX3397 treatment; NT = not treated during adolescence) (Graph title # = significant interaction between perinatal diet and adolescent treatment; HF * = main effect of perinatal high fat diet; PLX ^ = main effect of adolescent treatment; ^^p < 0.05 vs. HF NT; $ p < 0.05 significant overall correlation; ****p < 0.0125 adj)