MR-PheWAS estimates for novel associations, thromboembolic disease, and diabetes mellitus. Forest plots (A) of novel associations from the combined (eMERGE, UK Biobank, and MVP) European Ancestry cohort; (B) of arterial and venous thromboembolic disease phenotypes within the eMERGE cohort; and (C) diabetes phenotypes within the eMERGE cohort. For all panels, results are for the inverse variance weighted method. CI: confidence interval, eMERGE: electronic MEdical Records and GEnomics, Lp(a): lipoprotein(a), MR: Mendelian randomization, MVP: Million Veteran Program, OR: odds ratio, SD: standard deviation, UK: United Kingdom.