Table 2.

SNVs selected as genetic instruments for Lp(a) levels

				Zekavat et al 201822						UK Biobank‡
Chromosome 6, Position*	Variant	Effect allele	Non-effect allele	Beta	SE	P-value	MAF	Sample size	F-statistic	Beta	SE	P-value	MAF	Sample size	F-statistic
European Ancestry
160416196	rs73019695	A	T	0.298	0.049	1.28E-09	0.027	6440	36.84	0.208	0.008	3.57E-150	0.033	318922	681.16
160620141	rs75885118	C	T	−0.321	0.035	4.93E-20	0.054	6440	84.01	−0.165	0.007	5.09E-135	0.051	318922	611.56
160765055	rs572889	G	A	−0.364	0.061	2.42E-09	0.018	6440	35.60	−0.363	0.000	NC†	0.027	318922	NC†
161089307	rs56393506	T	C	0.487	0.021	1.62E-124	0.187	6440	563.28	1.153	0.000	NC†	0.171	318922	NC†
161304242	rs62435349	T	A	−0.362	0.027	2.16E-42	0.104	6440	186.19	−0.212	0.000	NC†	0.099	318922	NC†
Chromosome 6, Position*	Variant	Effect allele	Non-effect allele	Beta	SE	P-value	MAF	Sample size	F-statistic	Beta	SE	P-value	MAF	Sample size	F-statistic
African Ancestry
160901411	rs114067707	A	G	−0.621	0.077	1.08E-15	0.023	2832	64.28	−0.214	0.050	1.90E-05	0.024	5140	18.30
160946747	rs75143493	G	T	0.645	0.099	5.85E-11	0.013	2832	42.87	0.618	0.076	6.06E-16	0.009	5140	65.42
160986915	rs6938647	C	A	0.463	0.059	4.32E-15	0.041	2832	61.55	0.281	0.048	5.39E-09	0.027	5140	34.04
161025797	rs78347018	C	T	−0.760	0.059	2.14E-38	0.041	2832	167.89	−0.272	0.041	2.66E-11	0.031	5140	44.40
161087440	rs41269135	A	G	0.785	0.051	1.28E-53	0.053	2832	237.65	0.587	0.037	1.02E-56	0.039	5140	251.81

NC: not calculated, SE: standard error, MAF: minor allele frequency, UK: United Kingdom

^*Position in human genome assembly hg19 (GRCh37)

^†Unable to calculate as the reported SE in Pan-UK Biobank was provided as 0 at the given precision level in the summary statistics

^‡ https://pan.ukbb.broadinstitute.org