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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Circ Genom Precis Med. 2021 Jul 20;14(4):e003354. doi: 10.1161/CIRCGEN.120.003354

Table 2.

SNVs selected as genetic instruments for Lp(a) levels

Zekavat et al 201822 UK Biobank‡
Chromosome 6, Position* Variant Effect allele Non-effect allele Beta SE P-value MAF Sample size F-statistic Beta SE P-value MAF Sample size F-statistic
European Ancestry
160416196 rs73019695 A T 0.298 0.049 1.28E-09 0.027 6440 36.84 0.208 0.008 3.57E-150 0.033 318922 681.16
160620141 rs75885118 C T −0.321 0.035 4.93E-20 0.054 6440 84.01 −0.165 0.007 5.09E-135 0.051 318922 611.56
160765055 rs572889 G A −0.364 0.061 2.42E-09 0.018 6440 35.60 −0.363 0.000 NC† 0.027 318922 NC†
161089307 rs56393506 T C 0.487 0.021 1.62E-124 0.187 6440 563.28 1.153 0.000 NC† 0.171 318922 NC†
161304242 rs62435349 T A −0.362 0.027 2.16E-42 0.104 6440 186.19 −0.212 0.000 NC† 0.099 318922 NC†
Chromosome 6, Position* Variant Effect allele Non-effect allele Beta SE P-value MAF Sample size F-statistic Beta SE P-value MAF Sample size F-statistic
African Ancestry
160901411 rs114067707 A G −0.621 0.077 1.08E-15 0.023 2832 64.28 −0.214 0.050 1.90E-05 0.024 5140 18.30
160946747 rs75143493 G T 0.645 0.099 5.85E-11 0.013 2832 42.87 0.618 0.076 6.06E-16 0.009 5140 65.42
160986915 rs6938647 C A 0.463 0.059 4.32E-15 0.041 2832 61.55 0.281 0.048 5.39E-09 0.027 5140 34.04
161025797 rs78347018 C T −0.760 0.059 2.14E-38 0.041 2832 167.89 −0.272 0.041 2.66E-11 0.031 5140 44.40
161087440 rs41269135 A G 0.785 0.051 1.28E-53 0.053 2832 237.65 0.587 0.037 1.02E-56 0.039 5140 251.81

NC: not calculated, SE: standard error, MAF: minor allele frequency, UK: United Kingdom

*

Position in human genome assembly hg19 (GRCh37)

†

Unable to calculate as the reported SE in Pan-UK Biobank was provided as 0 at the given precision level in the summary statistics