Table 3.

Heterogeneity of MR estimates with combined results from both ancestry groups

Phenotype (phecode)	MR Method	I 2	Heterogeneity P-value
CHD (411)	IVW	0.69	0.071
	MR-Egger	0.83	0.015
	Weighted median	0.62	0.107
	Weighted mode	0.90	2.03E-03
CVD (433)	IVW	0.54	0.139
	MR-Egger	0.92	3.56E-04
	Weighted median	0.45	0.178
	Weighted mode	0.87	5.66E-03
PAD (443)	IVW	0	0.549
	MR-Egger	0.38	0.205
	Weighted median	0	0.588
	Weighted mode	0	0.693
AAA (442.11)	IVW	0	0.648
	MR-Egger	0	0.629
	Weighted median	0	0.406
	Weighted mode	0	0.766
Aortic valve disorders (395.2)	IVW	0.64	0.095
	MR-Egger	0.91	8.00E-04
	Weighted median	0	0.336
	Weighted mode	0.87	5.82E-03
Mitral valve disorders (395.1)	IVW	0.70	0.069
	MR-Egger	0.11	0.290
	Weighted median	0.64	0.096
	Weighted mode	0.59	0.120
Congestive heart failure (428)	IVW	0.70	0.069
	MR-Egger	0.58	0.125
	Weighted median	0.74	0.048
	Weighted mode	0.72	0.060
Chronic kidney disease (585.3)	IVW	0	0.728
	MR-Egger	0	0.921
	Weighted median	0	0.968
	Weighted mode	0	0.935

AAA: abdominal aortic aneurysm, CHD: coronary heart disease, CVD: cerebrovascular disease, IVW: inverse variance weighted, MR: Mendelian randomization, PAD: peripheral artery disease