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HJC0416 inhibited the STAT3 pathway
(A) HJC0416 decreased total and nuclear levels of phosphorylated STAT3 in LX-2 cells. (B) HJC0416 decreased total and nuclear levels of phosphorylated STAT3 in HSC-T6 cells. (C) HJC0416 decreases STAT3 signal transduction pathway activation. (D) STAT3 downstream targets c-myc and cyclin D1 expression are decreased after HJC0416 treatment. The results are representative of at least three different experiments.
