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HJC0416 inhibited pro-inflammatory cytokines and the NF-κB pathway
(B) ELISA for (A) IL-6 antibodies demonstrates that HJC0416 significantly inhibits LPS-induced expression. (B) IL-1ß and ICAM-1 expression is decreased after treatment with HJC0416. (C) HJC0416 decreases LPS-induced NF-κB nuclear translocation and DNA binding. (D) HJC0416 decreases LPS-induced NF-κB pathway activation. The results are representative of at least three different experiments.
