TABLE 3.
HRs for associations of change in adipose tissue radiodensity and mortality after colorectal cancer in the subset of patients that had follow-up images available (n = 1775)1
| Overall mortality | CRC-specific mortality | |||||
|---|---|---|---|---|---|---|
| Exposure | n/events | HR (95% CI) | P value | n/events | HR (95% CI) | P value |
| Change in VAT radiodensity between CT images, per SD (8 HU) | ||||||
| Increase > 1 SD | 234/113 | 1.53 (1.23–1.90) | 0.002 | 234/73 | 1.56 (1.19–2.06) | 0.002 |
| No change < 1 SD | 1398/431 | REF | 1398/257 | REF | ||
| Decrease > 1 SD | 143/59 | 1.11 (0.84–1.47) | 0.45 | 143/40 | 1.44 (1.02–2.02) | 0.036 |
| Change in SAT radiodensity between CT images, per SD (9 HU) | ||||||
| Increase > 1 SD | 165/93 | 1.88 (1.48–2.40) | <0.0001 | 165/61 | 2.00 (1.48–2.70) | <0.0001 |
| No change < 1 SD | 1426/ 435 | REF | 1426/260 | REF | ||
| Decrease > 1 SD | 184/75 | 1.20 (0.94–1.54) | 0.15 | 184/49 | 1.36 (1.00– 1.86) | 0.05 |
1
Data are over a median follow-up time after the second CT image of 8.6 years (minimum, 0.002 years; maximum 13.4 years). The models were adjusted for age, sex, race/ethnicity, colon compared with rectum cancer, cancer stage, Charlson Comorbidity Index, smoking status, receipt of chemotherapy and/or radiation, and days between the at-diagnosis and follow-up CT images, as well as changes in BMI squared and in adipose tissue area between images. CRC, colorectal cancer; HU, Hounsfield Unit; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue.