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. 2021 Jul 5;32(1):197–215. doi: 10.1093/cercor/bhab203

Figure 6 .

Figure 6

Fmr1 P12 KO mice exhibit enhanced sensitivity to ZOLP. (A,B) Representative traces of averaged sIPSCs from L2/3 pyramidal neurons before and after 100 nM ZOLP. (C) The effects of ZOLP on sIPSC amplitude across ages. No effects observed at P9–10, but significantly increased amplitude following ZOLP observed in Fmr1 KO mice starting at P12–13. (D) The weighted decay τ of averaged sIPSCs significantly increases with ZOLP across all ages for both WT and KO mice. The average values are summarized in Supplementary Table 2. *P < 0.05, **P < 0.01, ****P < 0.0001.