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. 2021 Nov 15;15:745050. doi: 10.3389/fnins.2021.745050

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Copyright © 2021 Dobryakova, Spivak, Zaichenko, Koryagina, Markevich, Stepanichev and Bolshakov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunostaining of hippocampal slices with antibody against GFP and DAPI staining in the hippocampus control rats (A) and rats with cholinergic deficit (B,C), which were transduced with AAV carrying either GFP alone (A,B) or NGF-IRES-GFP (C). The images of GFP staining (green) are superimposed over images of the same sections stained with DAPI (blue). (D) Shows NGF protein concentration determined by ELISA in the hippocampi of control (PBS-GFP, n = 8), 192IgG-saporin (SAP-GFP, n = 11), and NGF overexpressed rats (SAP-NGF, n = 10). Each point represents the mean ± SEM. ^∗Significant differences compared to PBS-GFP and SAP-GFP groups, p < 0.05; bar, 200 μm.