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. 2021 Nov 15;15:745050. doi: 10.3389/fnins.2021.745050

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Copyright © 2021 Dobryakova, Spivak, Zaichenko, Koryagina, Markevich, Stepanichev and Bolshakov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Shows that cholinergic deficit induced by 192IgG-saporin significantly suppressed LTP induction in VHC-CA1 pathway [SAP-GFP (n = 10) and PBS-GFP groups (n = 8)]. NGF overexpression (SAP-NGF group, n = 9) facilitates the induction of hippocampal LTP as compared with SAP-GFP group. In (B), the time course of PPF in PBS-GFP, SAP-GFP, and SAP-NGF groups. In (C–E), dotted lines illustrate the fEPSP after HFS and solid lines, before HFS. Each point represents the mean ± SEM. Percentage of basal fEPSP amplitude at 0 min; #significant differences against the baseline, p < 0.05.