TABLE 3.
CBF after a soy intervention and control period in a randomized, controlled crossover study with older men and women1
| Outcome | Intervention period, mL · 100 g−1 · min−1 | Control period, mL · 100 g−1 · min−1 | Mean difference, mL · 100 g−1 · min−1 | F(1, 19) | MSE | P value2 |
|---|---|---|---|---|---|---|
| Global CBF | 40.6 ± 8.7 | 41.2 ± 9.5 | −0.6 ± 5.2 | 0.38 | 13.81 | 0.567 |
| Gray matter CBF | 48.5 ± 10.3 | 49.2 ± 10.9 | −0.6 ± 6.0 | 0.33 | 14.11 | 0.593 |
| Left hemi CBF | 42.5 ± 8.9 | 43.1 ± 9.3 | −0.6 ± 5.6 | 0.30 | 16.14 | 0.570 |
| Right hemi CBF | 42.2 ± 9.3 | 42.9 ± 10.2 | −0.7 ± 5.6 | 0.34 | 12.71 | 0.542 |
| Cluster 1 CBF | 41.9 ± 9.1 | 30.8 ± 7.4 | 11.1 ± 12.4 | <0.001 | ||
| Cluster 2 CBF | 49.6 ± 12.4 | 37.6 ± 6.8 | 12.1 ± 15.0 | 0.002 | ||
| Cluster 3 CBF | 39.6 ± 11.3 | 26.9 ± 6.8 | 12.7 ± 14.3 | 0.005 | ||
| Cluster 4 CBF | 41.0 ± 10.1 | 28.6 ± 8.3 | 12.4 ± 14.5 | 0.009 |
1
n = 23. Values are means ± SDs. CBF, cerebral blood flow; hemi, hemisphere; MSE, mean square error.
2
Repeated-measures ANOVA with period and gender as between-subject factors and participant and treatment as fixed factors. Clusters were the result of a voxel-wise analysis within FSL applying a repeated-measures mixed-effects analysis using a general linear model with a single-group paired difference [FMRIB's Local Analysis of Mixed Effects (FLAME) stage 1 and 2], and a Z-threshold of 2.3 (P < 0.05). Family-wise error correction was performed based on smoothness estimates.