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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: J Invest Dermatol. 2021 Jan 22;141(7):1780–1791. doi: 10.1016/j.jid.2020.11.032

Figure 1. Short-term exposure to Western diet (WD) enhances the susceptibility to IL-23-mediated skin inflammation.

Figure 1.

(a) C57BL/6 mice were fed with a WD or a standard chow diet (CD) for 6 weeks and then injected with IL-23 minicircle DNA (MC) or control GFP MC. After MC delivery, mice were maintained on their respective diets for an additional 4 weeks. (b) Serum levels of IL-23 by ELISA of each group at 24 hours after MC delivery. (c) Body weight, (d) clinical photographs showing erythema and scales, (e) ear thickness, (f) image of H&E section (scale bars, 50 μm), (g) histological analysis of epidermal thickness, (h) representative images of immunohistochemical Ki-67 (scale bars, 50 μm) and (i) gene expression of K16 in ear skin. All of the data are presented as mean± SEM. 4 mice per group. Data are representative of two independent experiments. * p <0.05, ** p <0.01,*** p <0.001,ns, not significant, by using one-way ANOVA with Bonferroni’s test.