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. 2021 Nov 15;12:777083. doi: 10.3389/fphar.2021.777083

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Copyright © 2021 Sardu, Massetti, Testa, Martino, Castellano, Turriziani, Sasso, Torella, De Feo, Santulli, Paolisso and Marfella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The representation of the study outcomes at 1 year of follow-up in patients without type 2 diabetes mellitus (non-T2DM; green color) vs T2DM under sodium-glucose transporter 2 inhibitors (SLGT2-I users; red color) vs T2DM patients without sodium-glucose transporter 2 inhibitors (non-SLGT2-I users; blue color). We reported the percentage of events for all deaths, cardiac deaths, re-myocardial infarction (re-MI), stroke, revascularization, and composite endpoint. For interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α), we used the values as mean ± standard deviation. * Is for statistical significant (p-value <0.05) vs T2DM; ** is for statistical significant (p value < 0.05) comparing SGLT2-I users vs non-SLGT2-I users.