Table 3.
Inhibitory activities of C1–C7 against SARS-CoV-2 3CLpro.
 | ||||
|---|---|---|---|---|
| Compds | R2 | IC50 ± SD (μM)a | Ki (μM) | Inhibition mode |
| C1 | 5-Ph | 1.55 ± 0.21 | 6.09 | Mixed |
| C2 | 5-CHO | 1.81 ± 0.17 | 7.64 | Mixed |
| C3 | 4-CH3 | 10.23 ± 3.50 | – | – |
| C4 | 4-F | 5.39 ± 0.65 | – | – |
| C5 | 4-Cl | 4.71 ± 0.20 | – | – |
| C6 | 4-CN | 10.68 ± 0.46 | – | – |
| C7 | 4-NCH3CH3 | 5.50 ± 0.35 | – | – |
| disulfiram | – | 1.04 ± 0.03 | – | – |
a
The inhibitory effects of these compounds against SARS-CoV-2 3CLpro were determined by the FRET assay. The data are the mean ± SD from at least three independent experiments.