Table 4.
Inhibitory activities of 11 compounds against SARS-CoV 3CLpro.
| Compds | R1 | R2 | IC50 ± SD (μM)a |
|---|---|---|---|
| B2 | 4-Br Phenyl | 5-Ph | 17.66 ± 1.42 |
| B4 | 4-Br Phenyl | 5-Cl | 5.44 ± 0.36 |
| B6 | 4-Br Phenyl | 5-CHO | 3.20 ± 0.25 |
| B11 | 4-Br Phenyl | 4-F | 7.81 ± 0.51 |
| B12 | 4-Br Phenyl | 4-Cl | 4.06 ± 0.17 |
| B14 | 4-Br Phenyl | 4-CN | 7.12 ± 0.32 |
| B18 | 4-Br Phenyl | 4-NCH3CH3 | 5.92 ± 0.22 |
| B20 | 4-Br Phenyl | 4-Benzyl | 5.79 ± 0.35 |
| C1 | 4-Br Phenyl | 5-Ph | 5.35 ± 0.30 |
| C2 | 4-Br Phenyl | 5-CHO | 5.32 ± 0.22 |
| C5 | 4-Br Phenyl | 4-Cl | 10.49 ± 0.23 |
| Disulfiram | – | – | 6.72 ± 1.02 |
a
The inhibitory effects of these compounds against SARS-CoV 3CLpro were determined by the FRET assay. The data are the mean ± SD from at least three independent experiments.