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. 2021 Nov 15;12:689880. doi: 10.3389/fphar.2021.689880

FIGURE 1.

FIGURE 1

Effects of low-dose piperlongumine administration on food intake, body weight, fasting blood glucose and lipid levels in HFD-fed mice. Male C57BL/6J mice at 8 weeks of age were randomly allocated to three groups and fed with high-fat rodent chow with or without receiving an intraperitoneal injection of low-does piperlongumine (0.25 mg/kg/d) for 8 weeks. After 8 weeks treatment, the mice were subjected to various analyses. (A), Food intake during the 8 weeks experiments (n = 8–11). (B), Body weight during the 8 weeks experiments (n = 7–11). (C), Effect of piperlongumine on fasting blood glucose (n = 7–9). (D–F), Blood total cholesterol (TC) levels, triglyceride (TG) levels, low-density lipoprotein cholesterol (LDL-c) levels, and high-density lipoprotein cholesterol (HDL-c) levels after 8 weeks treatment (n = 5–9). Throughout, bars represent means; error bars represent SEM. Values were normalized to Con. *p < 0.05, **p < 0.01. Con, control mice; HF, HFD-fed mice; PIP, HFD-fed mice treated with piperlongumine.