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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Gut. 2008 Jul 29;57(11):1555–1560. doi: 10.1136/gut.2007.143941

Figure 2.

Figure 2

The chemokine CXCL12 is expressed in murine and human pancreatic intraepithelial neoplasia. Murine and human pancreata were examined for CXCL12 expression via immunohistochemistry (IHC). CXCL12 expression was present in all pancreatic intraepithelial neoplasia (PanIN) grades but there was no statistical difference in expression patterns between low grade and high grade PanIN. Panels designate varying degrees of PanIN. (A) mPanIN 1A (single asterisk) and mPanIN 1B (double asterisk). (B) Double staining of CXCR4/CXCL12 in a mouse PanIN 1B with CXCL12 in brown and CXCR4 in green, demonstrates concurrent expression of ligand and receptor, suggesting the possibility of an autocrine PanIN activation. (C), hPanIN 1B, and (D) hPanIN 2.