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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Gut. 2008 Jul 29;57(11):1555–1560. doi: 10.1136/gut.2007.143941

Figure 4.

Figure 4

Inhibition of MEK1/2 with U0126 leads to decreased expression of the chemokine receptor CXCR4 in pancreatic intraepithelial neoplasia (PanIN) cells. Immunoblotting of PanIN lysates that were treated with 100 μmol/l of U0126 revealed an 83% and 62% downregulation of CXCR4 at 16 h and 48 h, respectively when compared with untreated controls by densitometry. The inhibition of MEK1/2 was confirmed by the downregulation of phospho-extra-cellular signal-related kinase (ERK) (pERK), the direct downstream target of MEK signalling. Tubulin and total-ERK (tERK) served as loading controls.