Table 3.

Inhibitory activities (IC₅₀, μm) of compounds 4 a–4 f against Hsp90α, B‐Raf^WT, B‐Raf^V600E and PDHK1. Dose‐response curves of the active compounds are reported in Figure S2 in the Supporting Information.

Compound	IC50 Hsp90α [μm]	IC50 B‐RafWT [μm]	IC50 B‐RafV600E [μm]	IC50 PDHK1 [μm]
controls	0.009[a]	0.044[b]	0.006[b]	7.1[b]
4 a	0.007	inactive	inactive	28.7
4 b	1.7	inactive	inactive	inactive
4 c	1.1	inactive	inactive	inactive
4 d	0.03	inactive	inactive	38.3
4 e	0.008	inactive	inactive	29.4
4 f	0.5	inactive	inactive	inactive

Note: [a] Geldanamycin; [b] GW5074;