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. 2021 Dec;11(12):a038380. doi: 10.1101/cshperspect.a038380

Figure 4.

Figure 4.

Schematic of the open reading frames (ORFs) and encoded protein domain structures of segment 7 mRNAs (PR8 strain). Boxes represent ORFs in each of the three reading frames (Fr) or the major polypeptide species and their functional domains (partially shaded bars). Zigzag lines represent splice junctions. AUG codons are represented by vertical lines, colored according to the predicted strength of their Kozak translation initiation context (green, strong; amber, intermediate; red, weak). Purple bars indicate CUG codons thought to be used for translation initiation. Black arrows indicate AUGs known to be used for translation initiation for the indicated proteins. Gray arrows indicate AUG codons proposed to fire on the basis of ribosomal profiling data or (DRiPs) from T-cell epitope data. (A) Represents the first 350 nucleotides of the unspliced transcript. (B) Represents mRNA2 (M2). (C) Represents mRNA3. (D) Represents mRNA4.