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. 2014 May 8;85(1):87–94. doi: 10.2319/123113-955.1

Figure 4.

Figure 4. Piezo1 inhibitor, GsMTx4 (Gx), treatment is associated with reduced mechanical stress–induced osteoclastogenesis but not with TNF-α–induced osteoclastogenesis. Changes of mRNA profile of Cox2 (A), RANKL (C), OPG (D), and protein production of PGE2 (B) in hPDLCs after mechanical stress (12 hours) or TNF-α induction with or without addition of Gx. Values shown as mean ± SEM. n  =  3, * P  =  .05; ** P  =  .01; *** P  =  .001; **** P  =  .0001.

Piezo1 inhibitor, GsMTx4 (Gx), treatment is associated with reduced mechanical stress–induced osteoclastogenesis but not with TNF-α–induced osteoclastogenesis. Changes of mRNA profile of Cox2 (A), RANKL (C), OPG (D), and protein production of PGE2 (B) in hPDLCs after mechanical stress (12 hours) or TNF-α induction with or without addition of Gx. Values shown as mean ± SEM. n  =  3, * P  =  .05; ** P  =  .01; *** P  =  .001; **** P  =  .0001.