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. 2021 Nov 15;12:736196. doi: 10.3389/fimmu.2021.736196

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Copyright © 2021 Jeong, Jhun, Lee, Na, Choi, Cho, Lee, Lee, Park, You, Kim, Park, Kwon, Cho, Ji and Park

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microbial composition at the genus level in patients with different RF levels. (A–C) Comparison of the relative abundance of (A) Bifidobacterium, (B) Collinsella, and (C) Clostridium using the Kruskal–Wallis test. (D) Correlations between the relative abundance of each of the 20 most abundant genera and RF levels. Positive correlations are shown in green, and negative correlations are shown in pink. The numbers in bold indicate statistically significant correlations (p < 0.05). *p < 0.05; **p < 0.01; ***p < 0.001. NM, normal control; NG, RA patients showing 20 or less of RF level; LP, RA patients showing over 20 and not exceeding 60 of RF level; HP, RA patients showing over 60 of RF level.