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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: J Surg Res. 2020 Nov 7;259:500–508. doi: 10.1016/j.jss.2020.10.002

Figure 2. Transplantation of human intestinal organoids promotes expression of tight junction genes.

Figure 2.

RT-qPCR demonstrates significant increases in relative gene expression of various tight junction components (A. CLDN3, B. CLDN15, C. OCLN, D. TJP1/ZO-1) in transplanted HIOs (tHIOs) after four (n=6) or eight (n-4–5) weeks in vivo compared to HIOs after 28 days in vitro (n=7–8). There was no significant difference in relative gene expression of tight junction genes between tHIOs at four and eight weeks in vivo. Values are expressed as the mean ± SEM. *p<0.05, ***p<0.001, ns denotes not significant (p≥0.05).