Table 2.
Early allograft dysfunction univariate analysis for EAD risk factors.
| Item | Non-EAD | EAD | P-value |
|---|---|---|---|
| Recipient characteristics | |||
| Recipient age (Years) (median) | 58 (IQR 14) | 59 (IQR 10) | p = 0.074 |
| Body mass index (kg/m2) (median) | 25.10 (IQR 5.80) | 25.90 (IQR 6.00) | p = 0.034 |
| Recipient sex | p = 0.030 | ||
| Male | 75% (321) | 83% (157) | |
| Female | 25% (106) | 17% (32) | |
| MELD Score (mean) | 21.11 (SD 9.06) | 22.08 (SD 9.42) | p = 0.238 |
| CHILD Score | p < 0.001 | ||
| A | 18% (76) | 32% (61) | |
| B | 54% (230) | 41% (78) | |
| C | 28% (121) | 26% (50) | |
| AB0 | p = 0.795 | ||
| A | 41% (173) | 45% (84) | |
| B | 11% (46) | 10% (18) | |
| 0 | 41% (173) | 40% (74) | |
| AB | 6% (25) | 5% (9) | |
| Hepatitis C | p = 0.003 | ||
| Negative | 91% (387) | 97% (184) | |
| Positive | 9% (40) | 3% (5) | |
| Re-transplantation | 4% (18) | 11% (21) | p = 0.001 |
| Acute liver failure | 4% (15) | 5% (9) | p = 0.460 |
| Encephalopathy | 23% (97) | 20% (37) | p = 0.384 |
| Cirrhosis | 95% (407) | 93% (176) | p = 0.265 |
| Tumor | 30% (127) | 42% (80) | p = 0.002 |
| Hepatocellular carcinoma | 29% (123) | 42% (79) | p = 0.002 |
| Tumor entity | p = 0.029 | ||
| No tumor | 70% (301) | 58% (109) | |
| Hepatocellular carcinoma | 28% (120) | 41% (78) | |
| Cholangiocellular• carcinoma | <1% (3) | <1% (1) | |
| Neuroendocrine tumor | <1% (1) | . | |
| Liver metastases of colon• malignancy | . | . | |
| Other | <1% (2) | <1% (1) | |
| Tumor treatment | 28% (118) | 39% (73) | p = 0.007 |
| Transarterial chemoembolization | 15% (63) | 21% (40) | p = 0.049 |
| Radiofrequency ablation | 14% (61) | 21% (40) | p = 0.033 |
| Surgical risk score | p = 0.746 | ||
| None | 63% (269) | 59% (111) | |
| Low | 22% (94) | 23% (44) | |
| Middle | 5% (22) | 6% (12) | |
| High | 10% (42) | 12% (22) | |
| Portal vein open | p = 0.293 | ||
| Yes | 85% (365) | 83% (157) | |
| partial obstruction of portal vein trunk | 12% (50) | 11% (21) | |
| complete obstruction of portal vein trunk | 2% (9) | 4% (7) | |
| thrombosis right or left portal branch | <1% (3) | 2% (4) | |
| Donor characteristics | |||
| Donor age (years) (median) | 51 (IQR 25) | 53 (IQR 19) | p = 0.163 |
| Donor sex | p < 0.001 | ||
| Male | 52% (223) | 68% (129) | |
| Female | 48% (204) | 32% (60) | |
| Body mass index (kg/m2) (median) | 25.00 (IQR 4.80) | 27.00 (IQR 4.30) | p < 0.001 |
| Donor height (cm) (mean) | 172.99 (SD 8.82) | 175.68 (SD 8.52) | p < 0.001 |
| Donor weight (kg) (mean) | 75.97 (SD 13.96) | 85.58 (SD 14.39) | p < 0.001 |
| Steatosis | p < 0.001 | ||
| None | 63% (267) | 38% (71) | |
| Mild | 32% (133) | 37% (70) | |
| Medium | 5% (21) | 20% (38) | |
| Severe | . | 5% (10) | |
| Donor risk index (mean) | 1.80 (SD 0.34) | 1.93 (SD 0.51) | p = 0.001 |
| Donor artery | p = 0.286 | ||
| Normal anatomy | 81% (343) | 84% (159) | |
| Variance | 19% (83) | 16% (30) | |
| Allocation | p = 0.015 | ||
| Local | 43% (184) | 34% (65) | |
| Regional | 37% (159) | 50% (94) | |
| National | 20% (84) | 16% (30) | |
| Cause of death | p = 0.819 | ||
| Trauma | 24% (104) | 22% (42) | |
| Anoxia | 11% (48) | 10% (19) | |
| Cardiovascular accident | 63% (267) | 65% (123) | |
| Other | 2% (8) | 3% (5) | |
| Sodium (U/L) (mean) | 146.50 (SD 12.87) | 147.74 (SD 7.81) | p = 0.579 |
| Preservation solution | p = 0.843 | ||
| University of Wisconsin | 23% (98) | 23% (43) | |
| Histidine-tryptophan-•ketoglutarate | 75% (320) | 74% (140) | |
| Other | 2% (9) | 3% (6) | |
| Operative data | |||
| Simultaneous transplant | p = 0.185 | ||
| No | 94% (401) | 97% (184) | |
| Liver–kidney | 6% (25) | 3% (5) | |
| Heart–liver | . | . | |
| Multi-organ transplantation | <1% (1) | . | |
| Anhepatic phase (min) (mean) | 52.89 (SD 11.91) | 58.14 (SD 13.92) | p < 0.001 |
| Surgery duration (min) (mean) | 395.57 (SD 108.22) | 433.40 (SD 123.14) | p < 0.001 |
| Mass clamping ligamentum hepatoduodenale | <1% (2) | 1% (2) | p = 0.401 |
| Anastomosis time (min) (mean) | 44.49 (SD 10.78) | 52.61 (SD 25.35) | p < 0.001 |
| Cold Ischemia time (h) (mean) | 8.55 (SD 2.50) | 9.13 (SD 2.29) | p = 0.003 |
| Arterial lactate (mean) | 24.74 (SD 21.59) | 34.99 (SD 32.64) | p < 0.001 |
| Surgical experience | p = 0.145 | ||
| <50 liver transplantations | 35% (148) | 58% (109) | |
| ≥50 liver transplantations | 65% (279) | 42% (80) | |
Chi-square and Fisher's Exact Test for categorical variables; Mann-Whitney-U-Wilcoxon Test for continuous variables.
EAD, Early allograft dysfunction; MELD, Model for end-stage liver disease.