Table 2.
Cox’s regression analysis on cutaneous melanoma-specific survival patients, adjusting for sex, age, histological subtype, ulceration, mitotic count, CMM site, stage and TILs, as assessed at the patient’s enrolment.
| HR | 95% CI | P value | ||
|---|---|---|---|---|
| Sex | Female | 1.00 | – | – |
| Male | 1.67 | 0.87 - 3.21 | 0.120 | |
| Age | <40 | 1.00 | – | – |
| 40-49 | 1.45 | 0.17 - 13.55 | 0.743 | |
| 50-59 | 2.19 | 0.24 - 20.32 | 0.489 | |
| 60-69 | 3.28 | 0.41 - 26.39 | 0.265 | |
| 70-79 | 7.95 | 1.02 - 61.91 | 0.048 | |
| 80 or more | 3.58 | 0.43 - 29.79 | 0.238 | |
| CMM site | Hands/feet | 1.00 | – | – |
| Lower limbs | 0.34 | 0.11 - 1.04 | 0.058 | |
| Upper limbs | 0.34 | 0.10 - 1.15 | 0.083 | |
| Head | 1.83 | 0.62 - 5.40 | 0.272 | |
| Hands/feet | 1.00 | – | – | |
| Trunk | 0.39 | 0.15 - 1.06 | 0.066 | |
| CMM Histological subtype | Lentigo maligna | 1.00 | – | – |
| Nodular m. | 15.04 | 1.69 - 133.30 | 0.015 | |
| Superficial spreading m. | 12.61 | 1.42 - 112.02 | 0.023 | |
| NOS cutaneous m. | 6.07 | 0.46 - 79.67 | 0.170 | |
| Others | 3.26 | 0.16 - 67.66 | 0.444 | |
| CMM Ulceration | Present | 1.00 | – | – |
| Absent | 0.82 | 0.41 - 1.62 | 0.562 | |
| CMM Mitotic number | 0-2 | 1.00 | – | – |
| >2 | 6.85 | 2.21 - 21.28 | <0.001 | |
| CMM TILs | Absent | 1.00 | – | – |
| Present | 1.70 | 0.80 - 3.59 | 0.166 | |
| CMM TNM stage | I | 1.00 | – | – |
| II | 3.31 | 0.94 - 11.76 | 0.064 | |
| III | 10.51 | 3.16 - 35.02 | <0.001 | |
| IV | 117.17 | 25.30 - 542.62 | <0.001 | |
CMM, cutaneous melanoma; NOS, not otherwise specified; TILs, tumor infiltrating lymphocytes; m, melanoma.
HR, hazard ratio; Assumption of proportionality: p-value 0.577.