Table 1.
Characteristics of the synthetic dataset used for machine learning.
| Variable | Synthetic training data (n = 1,064) | Synthetic validation data (n = 456) | P -value |
|---|---|---|---|
| Age (years) | 66.6 [14.0] | 62.9 [15.6] | <0.001 |
| Gender (male) | 528 (49.6%) | 234 (51.3%) | 0.73 |
| ICU location | |||
| MICU | 213 (20.0%) | 73 (16.0%) | 0.13 |
| MICU/SICU | 92 (8.6%) | 33 (7.2%) | 0.40 |
| SICU | 105 (9.9%) | 47 (10.3%) | 0.81 |
| TSICU | 76 (7.1%) | 33 (7.2%) | 0.95 |
| CCU | 60 (5.6%) | 63 (13.8%) | <0.001 |
| CVICU | 137 (12.9%) | 45 (9.9%) | 0.14 |
| Other (NSICU or PACU) | 4 (0.4%) | 3 (0.7%) | 0.46 |
| Past medical history | |||
| Diabetes Mellitus | 162 (15.2%) | 72 (15.8%) | 0.81 |
| COPD | 15 (1.4%) | 6 (1.3%) | 0.89 |
| Chronic heart disease | 210 (19.7%) | 77 (16.9%) | 0.28 |
| Cerebrovascular disease | 88 (8.3%) | 25 (5.5%) | 0.08 |
| Peripheral vascular disease | 33 (3.1%) | 14 (3.1%) | 0.97 |
| Charlson comorbidity index | 5 (3–7) | 6 (4–7) | 0.01 |
| Cellulitis | 22 (2.1%) | 9 (2.0%) | 0.91 |
| Pressure ulcer | 381 (35.8%) | 142 (31.1%) | 0.22 |
| SOFA score (at MRSA screening) | 4 (2–6) | 4 (2–7) | 0.11 |
| APACHE III score (on admission) | 58 (41–78) | 55(40–75) | 0.26 |
| Admision from ED | 439 (41.3%) | 248 (54.4%) | 0.004 |
| Length of hospital days (at MRSA screening) | 3.0 [4.5] | 2.9 [4.0] | 0.39 |
| Length of ventilator days (at MRSA screening) | 1.9 [2.9] | 1.9 [2.6] | 0.03 |
| Prior antibitics use (before MRSA screening) | |||
| Quinolone | 75 (7.0%) | 30 (6.6%) | 0.76 |
| Macrolide | 25 (2.3%) | 9 (2.0%) | 0.66 |
| Carbapenem | 24 (2.3%) | 12 (2.6%) | 0.67 |
| Prior corticosteroids use (before MRSA screening) | 11 (1.0%) | 5 (1.1%) | 0.91 |
| Procedures (before MRSA screening) | |||
| Peripheral line | 675 (63.4%) | 348 (76.3%) | 0.03 |
| PICC line | 62 (5.8%) | 36 (7.9%) | 0.16 |
| CVC line | 284 (26.7%) | 96 (21.1%) | 0.07 |
| PAC line | 51 (4.8%) | 32 (7.0%) | 0.10 |
| Arterial line | 293 (27.5%) | 146 (32.0%) | 0.19 |
| Urinary catheter | 144 (13.5%) | 66 (14.5%) | 0.67 |
| Hemodialysis | 109 (10.2%) | 44 (9.6%) | 0.75 |
| Tracheostomy | 8 (0.8%) | 1 (0.2%) | 0.22 |
| Outcome | |||
| MRSA-positive on screening test | 532 (50.0%) | 228 (50.0%) | 1.0 |
All categorical variables are shown as n (%). A continuous variable (Age) is shown as mean [standard deviation]. ICU, Intensive Care Unit, MICU, Medical Intensive Care Unit, SICU, Surgical Intensive Care Unit, TSICU, Trauma Surgical Intensive Care Unit, CCU, Coronary Care Unit, CVICU, Cardiac Vascular Intensive Care Unit, NSICU, Neuro Surgical Intensive Care Unit, PACU, Post Anesthesia Care Unit, COPD:Chronic Obstructive Pulmonary Disease, SOFA, Sequential Organ Failure Assessment, MRSA, Methicillin-Resistant Staphylococcus aureus, APACHE, Acute Physiology And Chronic Health Evaluation, ED, Emergency Department, PICC, Peripherally Inserted Central Catheter, CVC, Central Venous Catheter, PAC, Pulmonary Artery Catheter.