FIGURE 5.

Ttyh1 prevents accelerated exhaustion of the elderly NSCs pool. (A) Immunofluorescence staining of brain sections of elder control and Ttyh1 KO mice at 12-months old (12 M). Sox2⁺GFAP⁺ NSCs, EGFR⁺ TAPs, DCX⁺ neuroblasts, Ki67 proliferating cells and CD24 ependymal cells were compared in neurogenic niche between control and Ttyh1 KO mice. (B) Statistics of immunofluorescence staining results in A. Scale bar = 50 μm in A. n = 4 for all experiments. Data are expressed as mean ± SEM. Statistical significance was calculated using an unpaired, two-tailed Student’s t-test. (∗) p < 0.05.