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The summary of reported microglial GPCRs in microglial activation of PD. GPCRs expressed in microglia containing A2A, A2B, P2X7, P2Y1, P2Y12, P2Y6, TLR1/2/4, and NLRP3 act as detrimental roles, promoting microglial activation, damaging DA neurons, while microglial A1, A3, P2X4, P2Y13, mGlu5, α2, β2, CB1, CB2, MT1, and MT2 play protective roles in neuroinflammation.
