Table 1.
Somatic revertant cases of WAS.
| Number of patients | Type of reversion | Revertant cell | Reference |
|---|---|---|---|
| 1 | Second-site mutation | Lymphocytes | (20) |
| 1 | Back mutation | CD4+T, CD8+T | (21) |
| 3 | A 6-bp deletion (DNA slippage) | CD4+T, CD8+T | (29, 31) |
| 2 | Second-site mutation (19-bp deletion) | CD4+T, CD8+T, B | (30, 32) |
| 1 | Back mutation (1-bp deletion) | NK | (33) |
| 1 | Second-site mutation | CD4+T, CD8+T, NK | (34) |
| 1 | Back mutation (1-bp insertion) | T, B, NK | (35) |
| 1 | Back mutation | CD4+T, CD8+T, γδT | (36) |
| 30 a | Back mutation or second-site mutation | T, B, NK | (22) |
| 2 | Multiple second-site mutations | CD4+T, CD8+T, B, NK | (23) |
| 1 | Multiple reversions (back mutation, site-specific substitutions and second-site mutations) | CD4+T, CD8+T, B | (24, 26) |
| 2 | Multiple second-site mutations | CD4+T, CD8+T, B | (25) |
| 1 | Second-site mutation | CD4+T, CD8+T | (27) |
| 1 | Back mutation | CD4+T, CD8+T, NK | (28) |
a
Some cases overlap.
WAS, Wiskott–Aldrich syndrome; NK, natural killer.